The first proof-of-concept PROTAC, PROTAC-1 was composed of an angiogenesis inhibitor, ovalicin, a covalent binder for the methionine aminopeptidase-2 (MetAP-2), and an IB phospho-peptide that is recognized by the E3 ligase, SCF -TRCP
Research applications include investigation of chemotherapy-induced senescence and its role in administration resistance and tumor recurrence
The 10-peptide complex targets expression lines, collagen synthesis, and skin firming delivering anti-aging results in one mask step
APLB Glutathione Niacinamide Facial Toner 160ml 1250 Refresh and hydrate your skin with this moisturizing toner , infused with Niacinamide, Centella Asiatica, and Rice Extract
Bharath and Nikolajczyk, 2020