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One study found that postmenopausal women using hormone therapy (HT) lost more weight with semaglutide than those not on HT

For women of childbearing potential, these medications are not recommended during pregnancy or breastfeeding, and discontinuation is advised at least 2 months before planned pregnancy for semaglutide and 1 month for tirzepatide

Mean Changes in Anthropometry and Cardiometabolic Parameters in Study 5 (Obesity or Overweight with Comorbidity After 20-week Run-in)1 with WEGOVY Injection Missing data were imputed from retrieved subjects of the same randomized treatment arm (RD-MI)

No, semaglutide-related fatigue is a normal metabolic adaptation and not dangerous

These tend to resolve without intervention and become less frequent as the body adapts to the medication