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Topamax Drug Interactions Certain medicines, including Monoamine oxidase inhibitors (MAOIs) such as isocarboxazid (Marplan), selegiline (Eldepryl, Emsam, Zelapar), phenelzine (Nardil), and tranylcypromine (Parnate), can interact with topiramate and phentermine

A doctor may adjust the medication dose, slow the titration schedule, review food timing, change constipation support, check labs, assess hydration, evaluate other medications, or pause treatment when needed

Ultimately, patients may be looking for a softer landing than stopping altogether

(1) Examination: Doctor examines and explains treatment details