A-Lokus Labrador Retriever Mutation: TYRP1-Gen

Mutation: TYRP1-Gen

❗ Noch kein DogCheck 4

affected puppies exhibit stereotypical positioning of limbs

dog is a carrier of recessive mutation and will transfer it to 50% of its offspring

blood in urine

A-Lokus Labrador Retriever Mutation: TYRP1-GenAgouti signal peptide (ASIP) or A Locus is responsible for many different colour patterns in dogs. Specific A Locus allele products can interact with functional MC1R and thus interfere with production of black melanin. Dogs have four different ASIP gene alleles with following dominance hierarchy: Ay > aw > at > a, meaning that the most dominant allele present will be expressed. Genes on A Locus (agouti) are expressed only if a dog on K Locus does not